Ontology highlight
ABSTRACT:
SUBMITTER: Rom A
PROVIDER: S-EPMC6841665 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Rom Aviv A Melamed Liliya L Gil Noa N Goldrich Micah Jonathan MJ Kadir Rotem R Golan Matan M Biton Inbal I Perry Rotem Ben-Tov RB Ulitsky Igor I
Nature communications 20191108 1
Chromodomain helicase DNA binding protein 2 (Chd2) is a chromatin remodeller implicated in neurological disease. Here we show that Chaserr, a highly conserved long noncoding RNA transcribed from a region near the transcription start site of Chd2 and on the same strand, acts in concert with the CHD2 protein to maintain proper Chd2 expression levels. Loss of Chaserr in mice leads to early postnatal lethality in homozygous mice, and severe growth retardation in heterozygotes. Mechanistically, loss ...[more]