Ontology highlight
ABSTRACT:
SUBMITTER: Rechkoblit O
PROVIDER: S-EPMC6841716 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Rechkoblit Olga O Johnson Robert E RE Buku Angeliki A Prakash Louise L Prakash Satya S Aggarwal Aneel K AK
Scientific reports 20191108 1
Cytarabine (AraC) is the mainstay chemotherapy for acute myeloid leukemia (AML). Whereas initial treatment with AraC is usually successful, most AML patients tend to relapse, and AraC treatment-induced mutagenesis may contribute to the development of chemo-resistant leukemic clones. We show here that whereas the high-fidelity replicative polymerase Polδ is blocked in the replication of AraC, the lower-fidelity translesion DNA synthesis (TLS) polymerase Polη is proficient, inserting both correct ...[more]