Ontology highlight
ABSTRACT:
SUBMITTER: Park SH
PROVIDER: S-EPMC6841964 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Park Si Hoon SH Park Jaehyun J Lee Sang Jae SJ Yang Woo Seok WS Park Sehan S Kim Kyungdo K Park Zee-Yong ZY Song Hyun Kyu HK
Scientific reports 20191108 1
The hydroxymethylation of cytosine bases plays a vital role in the phage DNA protection system inside the host Escherichia coli. This modification is known to be catalyzed by the dCMP hydroxymethylase from bacteriophage T4 (T4dCH); structural information on the complexes with the substrate, dCMP and the co-factor, tetrahydrofolate is currently available. However, the detailed mechanism has not been understood clearly owing to a lack of structure in the complex with a reaction intermediate. We ha ...[more]