Dataset Information

Effects of vitamin D supplementation on androgens in men with low testosterone levels: a randomized controlled trial.

ABSTRACT:

Purpose

It has been hypothesized that vitamin D is associated with androgen levels in men. We, therefore, aimed to evaluate whether vitamin D supplementation increases serum total testosterone (TT) levels in men with low TT levels at baseline.

Methods

The Graz Vitamin D&TT-RCT is a single-center, double-blind, randomized placebo-controlled trial conducted between March 2013 and November 2017 at the endocrine outpatient clinic at the Medical University of Graz, Austria. One-hundred healthy men with serum TT levels < 10.4 nmol/l and 25-hydroxyvitamin D [25(OH)D] levels < 75 nmol/l participated in the trial. Subjects were randomized to receive 20,000 IU of vitamin D3/week (n = 50) or placebo (n = 50) for 12 weeks. Primary outcome was TT measured using mass spectrometry. Secondary outcomes were free testosterone, free androgen index, sex hormone-binding globulin, estradiol, follicle-stimulating hormone, luteinizing hormone, metabolic characteristics, and body composition.

Results

Ninety-four men [mean age and 25(OH)D: 47 (± 12) years and 56.3 (± 18.3) nmol/l, respectively] completed the study. We found no significant treatment effect on serum TT or on the remaining secondary outcome variables.

Conclusion

Vitamin D treatment had no effect on serum TT levels in middle-aged healthy men with low TT levels.

SUBMITTER: Lerchbaum E

PROVIDER: S-EPMC6842386 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature

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Publications

Effects of vitamin D supplementation on androgens in men with low testosterone levels: a randomized controlled trial.

Lerchbaum Elisabeth E Trummer Christian C Theiler-Schwetz Verena V Kollmann Martina M Wölfler Monika M Heijboer Annemieke C AC Pilz Stefan S Obermayer-Pietsch Barbara B

European journal of nutrition 20181120 8

<h4>Purpose</h4>It has been hypothesized that vitamin D is associated with androgen levels in men. We, therefore, aimed to evaluate whether vitamin D supplementation increases serum total testosterone (TT) levels in men with low TT levels at baseline.<h4>Methods</h4>The Graz Vitamin D&TT-RCT is a single-center, double-blind, randomized placebo-controlled trial conducted between March 2013 and November 2017 at the endocrine outpatient clinic at the Medical University of Graz, Austria. One-hundred ...[more]

PMID: 30460609

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Dataset Information

Effects of vitamin D supplementation on androgens in men with low testosterone levels: a randomized controlled trial.

Purpose

Methods

Results

Conclusion

Publications

Effects of vitamin D supplementation on androgens in men with low testosterone levels: a randomized controlled trial.

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