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Molecular Senescence Is Associated With White Matter Microstructural Damage in Late-Life Depression.


ABSTRACT: OBJECTIVES:The authors aim to investigate the association between white matter integrity and accelerated brain aging in late-life depression. METHODS:The authors measured senescence-associated secretory phenotype (SASP) index proteins, cognitive performance, and MRI diffusion tensor imaging (DTI) measures of fractional anisotropy and mean diffusivity-based indices of white matter microstructure measures in 56 older adults with remitted late-life depression. RESULTS:Higher SASP index was significantly correlated with older age (r?=?0.42, p?=?0.001) and worse executive function performance (r = -0.27, p?=?0.04). After controlling for the effect of age, overall cognitive performance, and white matter hyperintensities, the association between SASP and left and right cingulate bundle mean diffusivity remained statistically significant. CONCLUSIONS:Our data suggest that, in the context of late-life depression, SASP proteins are associated with microstructural abnormalities in white matter tracts in brain and worse executive function performance.

SUBMITTER: Mendes-Silva AP 

PROVIDER: S-EPMC6842685 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature

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Molecular Senescence Is Associated With White Matter Microstructural Damage in Late-Life Depression.

Mendes-Silva Ana Paula AP   Mwangi Benson B   Aizenstein Howard H   Reynolds Charles F CF   Butters Meryl A MA   Diniz Breno S BS  

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 20190622 12


<h4>Objectives</h4>The authors aim to investigate the association between white matter integrity and accelerated brain aging in late-life depression.<h4>Methods</h4>The authors measured senescence-associated secretory phenotype (SASP) index proteins, cognitive performance, and MRI diffusion tensor imaging (DTI) measures of fractional anisotropy and mean diffusivity-based indices of white matter microstructure measures in 56 older adults with remitted late-life depression.<h4>Results</h4>Higher S  ...[more]

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