Molecular Senescence Is Associated With White Matter Microstructural Damage in Late-Life Depression.
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ABSTRACT:
SUBMITTER: Mendes-Silva AP
PROVIDER: S-EPMC6842685 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Publications
Molecular Senescence Is Associated With White Matter Microstructural Damage in Late-Life Depression.
Mendes-Silva Ana Paula AP Mwangi Benson B Aizenstein Howard H Reynolds Charles F CF Butters Meryl A MA Diniz Breno S BS
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 20190622 12
<h4>Objectives</h4>The authors aim to investigate the association between white matter integrity and accelerated brain aging in late-life depression.<h4>Methods</h4>The authors measured senescence-associated secretory phenotype (SASP) index proteins, cognitive performance, and MRI diffusion tensor imaging (DTI) measures of fractional anisotropy and mean diffusivity-based indices of white matter microstructure measures in 56 older adults with remitted late-life depression.<h4>Results</h4>Higher S ...[more]
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