Ontology highlight
ABSTRACT:
SUBMITTER: Maimaiti S
PROVIDER: S-EPMC6842794 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Maimaiti Shayida S Koshida Ryusuke R Ojima Masami M Kulathunga Kaushalya K Oishi Hisashi H Takahashi Satoru S
Experimental animals 20190516 4
Mammalian postnatal growth is regulated primarily by the growth hormone (GH)/insulin-like growth factor I (IGF-I) axis. MafB is a basic leucine zipper (bZip) transcription factor that has pleiotropic functions. Although MafB plays a critical role in fetal brain development, such as in guidance for hindbrain segmentation, its postnatal role in neurons remains to be elucidated. To investigate this, we used neuron-specific Mafb conditional knockout (cKO) mice. In addition to an approximately 50% ne ...[more]