Ontology highlight
ABSTRACT:
SUBMITTER: Borisek J
PROVIDER: S-EPMC6843770 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Borišek Jure J Saltalamacchia Andrea A Gallì Anna A Palermo Giulia G Molteni Elisabetta E Malcovati Luca L Magistrato Alessandra A
Biomolecules 20191021 10
The spliceosome accurately promotes precursor messenger-RNA splicing by recognizing specific noncoding intronic tracts including the branch point sequence (BPS) and the 3'-splice-site (3'SS). Mutations of Hsh155 (yeast)/SF3B1 (human), which is a protein of the SF3b factor involved in BPS recognition and induces altered BPS binding and 3'SS selection, lead to mis-spliced mRNA transcripts. Although these mutations recur in hematologic malignancies, the mechanism by which they change gene expressio ...[more]