Ontology highlight
ABSTRACT:
SUBMITTER: Vrselja Z
PROVIDER: S-EPMC6844189 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Vrselja Zvonimir Z Daniele Stefano G SG Silbereis John J Talpo Francesca F Morozov Yury M YM Sousa André M M AMM Tanaka Brian S BS Skarica Mario M Pletikos Mihovil M Kaur Navjot N Zhuang Zhen W ZW Liu Zhao Z Alkawadri Rafeed R Sinusas Albert J AJ Latham Stephen R SR Waxman Stephen G SG Sestan Nenad N
Nature 20190417 7752
The brains of humans and other mammals are highly vulnerable to interruptions in blood flow and decreases in oxygen levels. Here we describe the restoration and maintenance of microcirculation and molecular and cellular functions of the intact pig brain under ex vivo normothermic conditions up to four hours post-mortem. We have developed an extracorporeal pulsatile-perfusion system and a haemoglobin-based, acellular, non-coagulative, echogenic, and cytoprotective perfusate that promotes recovery ...[more]