Dataset Information

Effects of Cognitive Strategies on Neural Food Cue Reactivity in Adults with Overweight/Obesity.

ABSTRACT:

Objective

Functional magnetic resonance imaging (fMRI) studies of obesity have revealed key roles for reward-related and inhibitory control-related activity in response to food cues. This study examines how cognitive strategies impact neural food cue reactivity.

Methods

In a within-participants, block-design, fMRI paradigm, 30 participants (24 women; mean BMI?=?31.8) used four mind-sets while viewing food: "distract" (cognitive behavioral therapy based), "allow" (acceptance and commitment therapy based), "later" (focusing on long-term negative consequences), and "now" (control; focusing on immediate rewards). Participants rated cravings by noting urges to eat on four-point Likert scales after each block.

Results

Self-reported cravings significantly differed among all conditions (pairwise comparisons P?ConclusionsBecause focusing on negative long-term consequences led to the greatest decrease in cravings and increased inhibitory control, this may be a promising treatment strategy for obesity.

SUBMITTER: Demos McDermott KE

PROVIDER: S-EPMC6844254 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature

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Publications

Effects of Cognitive Strategies on Neural Food Cue Reactivity in Adults with Overweight/Obesity.

Demos McDermott Kathryn E KE Lillis Jason J McCaffery Jeanne M JM Wing Rena R RR

Obesity (Silver Spring, Md.) 20190814 10

<h4>Objective</h4>Functional magnetic resonance imaging (fMRI) studies of obesity have revealed key roles for reward-related and inhibitory control-related activity in response to food cues. This study examines how cognitive strategies impact neural food cue reactivity.<h4>Methods</h4>In a within-participants, block-design, fMRI paradigm, 30 participants (24 women; mean BMI = 31.8) used four mind-sets while viewing food: "distract" (cognitive behavioral therapy based), "allow" (acceptance and co ...[more]

PMID: 31411800

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Project description:Background/objectivesCentral insulin action influences cognitive processes, peripheral metabolism, and eating behavior. However, the contribution of obesity and sex on central insulin-mediated neural food cue processing still remains unclear.Subjects/methodsIn a randomized within-participant design, including two visits, 60 participants (30 women, BMI 18-32 kg/m2, age 21-69 years) underwent a functional MRI task measuring blood oxygen level-dependent (BOLD) signal in response to visual food cues after intranasal insulin or placebo spray administration. Central insulin action was defined as the neural BOLD response to food cues after insulin compared to placebo administration. Afterwards, participants were asked to rate the food cues for desire to eat (i.e., wanting rating). For statistical analyses, participants were grouped according to BMI and sex.ResultsFood cue reactivity in the amygdala showed higher BOLD activation in response to central insulin compared to placebo. Furthermore, women with overweight and obesity and men of normal weight showed higher BOLD neural food cue responsivity to central insulin compared to placebo. Higher central insulin action in the insular cortex was associated with better peripheral insulin sensitivity and higher cognitive control. Moreover, central insulin action in the dorsolateral prefrontal cortex (DLPFC) revealed significant sex differences. In response to central insulin compared to placebo, men showed lower DLPFC BOLD activity, whereas women showed higher DLPFC activity in response to highly desired food cues. On behavioral level, central insulin action significantly reduced hunger, whereas the desire to eat, especially for low caloric food cues was significantly higher with central insulin than with placebo.ConclusionsObesity and sex influenced the central insulin-mediated neural BOLD activity to visual food cues in brain regions implicated in reward and cognitive control. These findings show that central insulin action regulates food response differentially in men and women, which may have consequences for metabolism and eating behavior.

Dataset Information

Effects of Cognitive Strategies on Neural Food Cue Reactivity in Adults with Overweight/Obesity.

Objective

Methods

Results

Publications

Effects of Cognitive Strategies on Neural Food Cue Reactivity in Adults with Overweight/Obesity.

Similar Datasets

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