MicroRNA-142-3p suppresses endometriosis by regulating KLF9-mediated autophagy in vitro and in vivo.
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ABSTRACT:
SUBMITTER: Ma L
PROVIDER: S-EPMC6844572 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Publications
MicroRNA-142-3p suppresses endometriosis by regulating KLF9-mediated autophagy <i>in vitro</i> and <i>in vivo</i>.
Ma Lin L Li Zaiyi Z Li Weihao W Ai Jing J Chen Xiaoxuan X
RNA biology 20190825 12
The detailed pathogenesis of endometriosis remains largely unclear despite decades of research. Recent studies have demonstrated that miRNAs plays an important role in endometriosis. The expression of miR-142-3p was decreased in ectopic endometrial tissues, while KLF9 and VEGFA expression levels were increased. Overexpression of miR-142-3p or knockdown of KLF9 significantly suppressed CRL-7566 cell proliferation and metastasis, induced cell apoptosis, and decreased both cell autophagy and vascul ...[more]
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