Ontology highlight
ABSTRACT:
SUBMITTER: Owens N
PROVIDER: S-EPMC6844645 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Owens Nick N Papadopoulou Thaleia T Festuccia Nicola N Tachtsidi Alexandra A Gonzalez Inma I Dubois Agnes A Vandormael-Pournin Sandrine S Nora Elphège P EP Bruneau Benoit G BG Cohen-Tannoudji Michel M Navarro Pablo P
eLife 20191010
The access of Transcription Factors (TFs) to their cognate DNA binding motifs requires a precise control over nucleosome positioning. This is especially important following DNA replication and during mitosis, both resulting in profound changes in nucleosome organization over TF binding regions. Using mouse Embryonic Stem (ES) cells, we show that the TF CTCF displaces nucleosomes from its binding site and locally organizes large and phased nucleosomal arrays, not only in interphase steady-state b ...[more]