Dinucleotide evolutionary dynamics in influenza A virus.
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ABSTRACT:
SUBMITTER: Gu H
PROVIDER: S-EPMC6845147 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Publications
Dinucleotide evolutionary dynamics in influenza A virus.
Gu Haogao H Fan Rebecca L Y RLY Wang Di D Poon Leo L M LLM
Virus evolution 20190701 2
Significant biases of dinucleotide composition in many RNA viruses including influenza A virus have been reported in recent years. Previous studies have showed that a codon-usage-altered influenza mutant with elevated CpG usage is attenuated in mammalian <i>in vitro</i> and <i>in vivo</i> models. However, the relationship between dinucleotide preference and codon usage bias is not entirely clear and changes in dinucleotide usage of influenza virus during evolution at segment level are yet to be ...[more]
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