Ontology highlight
ABSTRACT:
SUBMITTER: Hahn J
PROVIDER: S-EPMC6847259 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Hahn Jaeseung J Shih William M WM
Nucleic acids research 20191101 20
DNA-based devices often operate through a series of toehold-mediated strand-displacement reactions. To achieve cycling, fluidic mixing can be used to introduce 'recovery' strands to reset the system. However, such mixing can be cumbersome, non-robust, and wasteful of materials. Here we demonstrate mixing-free thermal cycling of DNA devices that operate through associative strand-displacement cascades. These cascades are favored at low temperatures due to the primacy of a net increase in base pai ...[more]