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Corticosteroids for Posttransplant Immune Reconstitution Syndrome in Cryptococcus gattii Meningoencephalitis: Case Report and Literature Review.


ABSTRACT: Cryptococcus gattii represents an emerging fungal pathogen of immunocompromised and immunocompetent hosts in the United States. To our knowledge, this is the first case of posttransplant immune reconstitution syndrome due to C. gattii meningoencephalitis successfully treated with corticosteroids. We also report successful maintenance phase treatment with isavuconazole, a novel triazole, following fluconazole-induced prolonged QT syndrome.

SUBMITTER: Canfield GS 

PROVIDER: S-EPMC6847472 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature

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Corticosteroids for Posttransplant Immune Reconstitution Syndrome in <i>Cryptococcus gattii</i> Meningoencephalitis: Case Report and Literature Review.

Canfield Gregory S GS   Henao-Martínez Andrés F AF   Franco-Paredes Carlos C   Zhelnin Kristen K   Wilson Michael L ML   Shihadeh Katherine C KC   Wyles David D   Gardner Edward M EM  

Open forum infectious diseases 20191023 11


<i>Cryptococcus gattii</i> represents an emerging fungal pathogen of immunocompromised and immunocompetent hosts in the United States. To our knowledge, this is the first case of posttransplant immune reconstitution syndrome due to <i>C. gattii</i> meningoencephalitis successfully treated with corticosteroids. We also report successful maintenance phase treatment with isavuconazole, a novel triazole, following fluconazole-induced prolonged QT syndrome. ...[more]

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