Improved annotation of protein-coding genes boundaries in metazoan mitochondrial genomes.
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ABSTRACT:
SUBMITTER: Donath A
PROVIDER: S-EPMC6847864 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Publications
Improved annotation of protein-coding genes boundaries in metazoan mitochondrial genomes.
Donath Alexander A Jühling Frank F Al-Arab Marwa M Bernhart Stephan H SH Reinhardt Franziska F Stadler Peter F PF Middendorf Martin M Bernt Matthias M
Nucleic acids research 20191101 20
With the rapid increase of sequenced metazoan mitochondrial genomes, a detailed manual annotation is becoming more and more infeasible. While it is easy to identify the approximate location of protein-coding genes within mitogenomes, the peculiar processing of mitochondrial transcripts, however, makes the determination of precise gene boundaries a surprisingly difficult problem. We have analyzed the properties of annotated start and stop codon positions in detail, and use the inferred patterns t ...[more]
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