Meta-analysis of reward processing in major depressive disorder reveals distinct abnormalities within the reward circuit.

ABSTRACT: Many neuroimaging studies have investigated reward processing dysfunction in major depressive disorder. These studies have led to the common idea that major depressive disorder is associated with blunted responses within the reward circuit, particularly in the ventral striatum. Yet, the link between major depressive disorder and reward-related responses in other regions remains inconclusive, thus limiting our understanding of the pathophysiology of major depressive disorder. To address this issue, we performed a coordinate-based meta-analysis of 41 whole-brain neuroimaging studies encompassing reward-related responses from a total of 794 patients with major depressive disorder and 803 healthy controls. Our findings argue against the common idea that major depressive disorder is primarily l

SUBMITTER: Ng TH 

PROVIDER: S-EPMC6848107 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature