Chronic Exposure to High Altitude: Synaptic, Astroglial and Memory Changes.
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ABSTRACT:
SUBMITTER: Sharma R
PROVIDER: S-EPMC6848138 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Publications
Chronic Exposure to High Altitude: Synaptic, Astroglial and Memory Changes.
Sharma Rupali R Cramer Nathan P NP Perry Bayley B Adahman Zahra Z Murphy Erin K EK Xu Xiufen X Dardzinski Bernard J BJ Galdzicki Zygmunt Z Perl Daniel P DP Dickstein Dara L DL Iacono Diego D
Scientific reports 20191111 1
Long-term operations carried out at high altitude (HA) by military personnel, pilots, and astronauts may trigger health complications. In particular, chronic exposure to high altitude (CEHA) has been associated with deficits in cognitive function. In this study, we found that mice exposed to chronic HA (5000 m for 12 weeks) exhibited deficits in learning and memory associated with hippocampal function and were linked with changes in the expression of synaptic proteins across various regions of t ...[more]
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