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Range Variability in CMR Feature Tracking Multilayer Strain across Different Stages of Heart Failure.


ABSTRACT: Heart failure (HF) is associated with progressive ventricular remodeling and impaired contraction that affects distinctly various regions of the myocardium. Our study applied cardiac magnetic resonance (CMR) feature tracking (FT) to assess comparatively myocardial strain at 3 distinct levels: subendocardial (Endo-), mid (Myo-) and subepicardial (Epi-) myocardium across an extended spectrum of patients with HF. 59 patients with HF, divided into 3 subgroups as follows: preserved ejection fraction (HFpEF, N?=?18), HF with mid-range ejection fraction (HFmrEF, N?=?21), HF with reduced ejection fraction (HFrEF, N?=?20) and a group of age- gender- matched volunteers (N?=?17) were included. Using CMR FT we assessed systolic longitudinal and circumferential strain and strain-rate at Endo-, Myo- and Epi- levels. Strain values were the highest in the Endo- layer and progressively lower in the Myo- and Epi- layers respectively, this gradient was present in all the patients groups analyzed but decreased progressively in HFmrEF and further on in HFrEF groups. GLS decreased with the severity of the disease in all 3 layers: Normal?>?HFpEF?>?HFmrEF?>?HFrEF (Endo-: -23.0?±?3.5?>?-20.0?±?3.3?>?-16.4?±?2.2?>?-11.0?±?3.2, p??-17.5.0?±?2.6?>?-14.5?±?2.1?>?-9.6?±?2.7, p??-12.2?±?2.1?>?-10.6?±?2.3?>?-7.7?±?2.3, p??HFmrEF?>?HFrEF (Endo-: -34.5?±?6.2?>?-20.0?±?4.2?>?12.3?±?4.2, p??-13.0?±?3.4?>?-8.0?±?2.7. p??-7.9?±?2.3?>?-4.5?±?1.9. p?

SUBMITTER: Tanacli R 

PROVIDER: S-EPMC6848170 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature

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Range Variability in CMR Feature Tracking Multilayer Strain across Different Stages of Heart Failure.

Tanacli Radu R   Hashemi Djawid D   Lapinskas Tomas T   Edelmann Frank F   Gebker Rolf R   Pedrizzetti Gianni G   Schuster Andreas A   Nagel Eike E   Pieske Burkert B   Düngen Hans-Dirk HD   Kelle Sebastian S  

Scientific reports 20191111 1


Heart failure (HF) is associated with progressive ventricular remodeling and impaired contraction that affects distinctly various regions of the myocardium. Our study applied cardiac magnetic resonance (CMR) feature tracking (FT) to assess comparatively myocardial strain at 3 distinct levels: subendocardial (Endo-), mid (Myo-) and subepicardial (Epi-) myocardium across an extended spectrum of patients with HF. 59 patients with HF, divided into 3 subgroups as follows: preserved ejection fraction  ...[more]

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