Increased CD83 expression of CD34-positive monocytes in donors during peripheral blood stem cell mobilization in humans.

ABSTRACT: CD34-positive monocytes (CD34+mono) have recently been identified in grafts mobilized by granulocyte-colony stimulating factor. We analyzed transplant outcomes of 73 patients whose donor's peripheral blood cells were cryopreserved during mobilization. CD34+mono was detected more frequently in male donors (67% vs. 40%, P = 0.03), while the detection of CD34+mono in donors was not associated with the patient background. Although there was no significant difference in overall survival in the whole cohort, the detection of CD34+mono in donors were significantly associated with a decreased risk of non-relapse mortality (HR 0.23, P = 0.035). Fatal infectious events tended to be less frequent in donors with CD34+mono. Gene expression profile analyses of CD34+mono in humans revealed that the expre

SUBMITTER: Nakasone H 

PROVIDER: S-EPMC6848192 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature