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Whole exome sequencing revealed a pathogenic variant in a gene related to malignant hyperthermia in a Vietnamese cardiac surgical patient: A case report.

ABSTRACT: Introduction:Malignant hyperthermia (MH) is a rare autosomal dominant pharmacogenetic disorder which known associated with some genes such as CACNA1S and RYR1. Using whole exome analysis, we aimed to find out the genetic variant data in a malignant hyperthermia patient undergoing cardiac surgery. Presentation of case:Patient was 59 years old male with dull left chest pain, mild breathing difficulty, thrombosis in the left atrium, mitral valve stenosis that needed a surgery to remove the thrombus and replace the mitral valve. After 5-h operation of left mitral heart valve replacement using both intravenous and inhaled anaesthetics, the patient showed suddenly hyperthermia (39.5?°C), low blood pressure (90/50?mmHg), heavy sweating, 1 mm dilated pupils on both sides, positive light reflection. Whole exome analysis showed 96,286 of SNPs including 11,705 of synonymous variants, 11,388 of missense variants, 106 of stop gained, and 39 of stop lost. One variant of RYR1 gene was found as mutation point at c.7048G?>?A (p.Ala2350Thr) known related to MH. Discussion:This was a rare case of MH during cardiac surgery reported in Vietnam that might related to mutation point at c.7048G?>?A (p.Ala2350Thr) of RYR1 gene. Conclusion:Patient carried a mutant of RYR1 gene could possibly lead to MH development post anaesthesia of cardiac surgery.

SUBMITTER: Nguyen TT 

PROVIDER: S-EPMC6849130 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature

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Whole exome sequencing revealed a pathogenic variant in a gene related to malignant hyperthermia in a Vietnamese cardiac surgical patient: A case report.

Nguyen Tran-Thuy TT   Le Ngoc-Thanh NT   Nguyen Thuy-Mau Thi TT   Nguyen Huy-Hoang HH   Nguyen Kim-Lien Thi KT   Dinh Long Doan LD   Nguyen The-Binh TB   Do Anh Tien AT   Nguyen Cong Huu CH   Nguyen Trung-Hieu TH   Pham Hong-Nhung Thi HT   Vu Thom Thi TT  

Annals of medicine and surgery (2012) 20191106

<h4>Introduction</h4>Malignant hyperthermia (MH) is a rare autosomal dominant pharmacogenetic disorder which known associated with some genes such as <i>CACNA1S</i> and <i>RYR1</i>. Using whole exome analysis, we aimed to find out the genetic variant data in a malignant hyperthermia patient undergoing cardiac surgery.<h4>Presentation of case</h4>Patient was 59 years old male with dull left chest pain, mild breathing difficulty, thrombosis in the left atrium, mitral valve stenosis that needed a s  ...[more]