Canonical DNA minor groove insertion of bisbenzamidine-Ru(ii) complexes with chiral selectivity.
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ABSTRACT:
SUBMITTER: Sanchez MI
PROVIDER: S-EPMC6849638 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
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Canonical DNA minor groove insertion of bisbenzamidine-Ru(ii) complexes with chiral selectivity.
Sánchez Mateo I MI Rama Gustavo G Calo-Lapido Renata R Ucar Kübra K Lincoln Per P López Miguel Vázquez MV Melle-Franco Manuel M Mascareñas José L JL Vázquez M Eugenio ME
Chemical science 20190801 37
We report the first Ru(ii) coordination compounds that interact with DNA through a canonical minor groove insertion mode and with selectivity for A/T rich sites. This was made possible by integrating a bis-benzamidine minor groove DNA-binding agent with a ruthenium(ii) complex. Importantly, one of the enantiomers (Δ-[Ru(bpy)<sub>2</sub> <b>b4bpy</b>]<sup>2+</sup>, <b>Δ-4Ru</b>) shows a considerably higher DNA affinity than the parent organic ligand and the other enantiomer, particularly for the ...[more]
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