Ontology highlight
ABSTRACT:
SUBMITTER: Meadows MK
PROVIDER: S-EPMC6849640 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Meadows Margaret K MK Sun Xiaolong X Kolesnichenko Igor V IV Hinson Caroline M CM Johnson Kenneth A KA Anslyn Eric V EV
Chemical science 20190813 38
A kinetic analysis of a "declick" reaction is described. Compound <b>1</b>, previously reported to couple an amine and a thiol (<i>i.e.</i> "click") under mild aqueous conditions to create <b>2</b>, undergoes release of the unaltered coupling partners upon triggering with dithiothreitol (<b>DTT</b>). In the study reported herein various aniline derivatives possessing para-electron donating and withdrawing groups were used as the amines. UV/vis spectroscopy of the declick reaction shows time-depe ...[more]