Ontology highlight
ABSTRACT:
SUBMITTER: Mijnes J
PROVIDER: S-EPMC6849652 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Mijnes Jolein J Tiedemann Janina J Eschenbruch Julian J Gasthaus Janina J Bringezu Sarah S Bauerschlag Dirk D Maass Nicolai N Arnold Norbert N Weimer Jörg J Anzeneder Tobias T Fasching Peter A PA Rübner Matthias M Bruno Benjamin B Heindrichs Uwe U Freres Jennifer J Schulz Hanna H Hilgers Ralf-Dieter RD Ortiz-Brüchle Nadina N von Serenyi Sonja S Knüchel Ruth R Kloten Vera V Dahl Edgar E
Oncotarget 20191105 60
<h4>Introduction</h4>Mammography is the gold standard for early breast cancer detection, but shows important limitations. Blood-based approaches on basis of cell-free DNA (cfDNA) provide minimally invasive screening tools to characterize epigenetic alterations of tumor suppressor genes and could serve as a liquid biopsy, complementing mammography.<h4>Methods</h4>Potential biomarkers were identified from The Cancer Genome Atlas (TCGA), using HumanMethylation450-BeadChip data. Promoter methylation ...[more]