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ABSTRACT: Rationale
Pulmonary arterial hypertension (PAH) is characterized in part by increased dead space ventilation, which can be estimated noninvasively at the bedside by measurement of end-tidal CO2 (ETco2).Objectives
Prior work has demonstrated that ETco2 is lower in patients with PAH than in control patients, but whether ETco2 has prognostic value is unknown. We hypothesized that lower measurements of ETco2 in patients with PAH correlate with worse long-term outcomes.Methods
Patients with PAH seen in our referral clinic were prospectively recruited for ETco2 measurement between September 2009 and February 2010. Vital status as of July 2015 was documented using medical records and the Social Security Death Index.Results
Eighty-two patients were followed for a median of 60 months. Twenty-six patients died, and two were lost to follow-up. Patients who died were more likely to be older (58.5?±?14.9 vs. 47.6?±?12.2 yr; P?2 in survivors was 30.5?±?4.8 mm Hg, whereas mean ETco2 in patients who died was 27.1?±?4.2 mm Hg (P?=?0.004). After stratification by median baseline ETco2 of 29 mm Hg, survival in each group was analyzed. Patients with lower ETco2 had shorter survival (P?=?0.006). Cox regression analysis with ETco2 as a continuous variable revealed the hazard ratio to be 0.88 (95% confidence interval, 0.80-0.97; P?=?0.006). In 52 patients with more than one measurement a median of 17 months apart, ETco2 was unchanged.Conclusions
Our single-center data suggest that lower ETco2 is associated with shorter survival and that ETco2 is stable over time in patients with PAH.
SUBMITTER: Welch CE
PROVIDER: S-EPMC6850742 | biostudies-literature | 2017 Jun
REPOSITORIES: biostudies-literature
Annals of the American Thoracic Society 20170601 6
<h4>Rationale</h4>Pulmonary arterial hypertension (PAH) is characterized in part by increased dead space ventilation, which can be estimated noninvasively at the bedside by measurement of end-tidal CO<sub>2</sub> (ETco<sub>2</sub>).<h4>Objectives</h4>Prior work has demonstrated that ETco<sub>2</sub> is lower in patients with PAH than in control patients, but whether ETco<sub>2</sub> has prognostic value is unknown. We hypothesized that lower measurements of ETco<sub>2</sub> in patients with PAH ...[more]