Ontology highlight
ABSTRACT:
SUBMITTER: Wang Y
PROVIDER: S-EPMC6851233 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Wang Yiyan Y Ni Chaobo C Li Xiaoheng X Lin Zhenkun Z Zhu Qiqi Q Li Linxi L Ge Ren-Shan RS
Frontiers in pharmacology 20191106
Male fetal Leydig cells in the testis secrete androgen and insulin-like 3, determining the sexual differentiation. The abnormal development of fetal Leydig cells could lead to the reduction of androgen and insulin-like 3, thus causing the male reproductive tract anomalies in male neonates, including cryptorchidism and hypospadias. Environmental pollutants, such as phthalic acid esters (phthalates), can perturb the development and differentiated function of Leydig cells, thereby contributing to t ...[more]