Harnessing evolutionary diversification of primary metabolism for plant synthetic biology.

ABSTRACT: Plants produce numerous natural products that are essential to both plant and human physiology. Recent identification of genes and enzymes involved in their biosynthesis now provides exciting opportunities to reconstruct plant natural product pathways in heterologous systems through synthetic biology. The use of plant chassis, although still in infancy, can take advantage of plant cells' inherent capacity to synthesize and store various phytochemicals. Also, large-scale plant biomass production systems, driven by photosynthetic energy production and carbon fixation, could be harnessed for industrial-scale production of natural products. However, little is known about which plants could serve as ideal hosts and how to optimize plant primary metabolism to efficiently provide precursors for t

SUBMITTER: Maeda HA 

PROVIDER: S-EPMC6851331 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature