Dataset Information

Capturing the trend of mHealth research using text mining.

ABSTRACT: Background:With the increasing development and use of mobile technologies, an increasing amount of research on mobile health is being conducted. The purpose of the study was to capture the trends in mHealth research by mining terms related to medical conditions, interventions, study populations, and the relationships between these terms. Methods:This study analyzed 5,600 journal articles published in Web of Science from 2008 to 2018. Using text mining techniques, a total of 39,292 terms extracted from the titles and abstracts of the journal articles were independently reviewed to identify meaningful terms related to medical conditions, interventions, and study populations. Results:A total of 48 different types of medical conditions were identified in the dataset. Mood disorders appeared to be the most frequently identified medical condition in mHealth research. Thirty interventions were identified. Cell phone-, SMS-, and Internet-based interventions appeared to be the most prominent types, and "female" appeared to be the most frequently identified term related to the studied population. Females appeared to have been studied in the widest range of medical conditions, including pregnancy issues, overnutrition, neoplasms, and AIDS. Older adults were the least studied population in mHealth. Conclusions:Knowledge gaps that have not been explored in previous studies in mHealth research were identified, which should be addressed by researchers.

SUBMITTER: Park H

PROVIDER: S-EPMC6851422 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Capturing the trend of mHealth research using text mining.

Park Hyejin H Park Min Sook MS

mHealth 20191011

<h4>Background</h4>With the increasing development and use of mobile technologies, an increasing amount of research on mobile health is being conducted. The purpose of the study was to capture the trends in mHealth research by mining terms related to medical conditions, interventions, study populations, and the relationships between these terms.<h4>Methods</h4>This study analyzed 5,600 journal articles published in Web of Science from 2008 to 2018. Using text mining techniques, a total of 39,292 ...[more]

PMID: 31728383

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Project description:BackgroundStudies using Taiwan's National Health Insurance (NHI) claims data have expanded rapidly both in quantity and quality during the first decade following the first study published in 2000. However, some of these studies were criticized for being merely data-dredging studies rather than hypothesis-driven. In addition, the use of claims data without the explicit authorization from individual patients has incurred litigation.ObjectiveThis study aimed to investigate whether the research output during the second decade after the release of the NHI claims database continues growing, to explore how the emergence of open access mega journals (OAMJs) and lawsuit against the use of this database affect the research topics and publication volume and to discuss the underlying reasons.MethodsPubMed was used to locate publications based on NHI claims data between 1996 and 2017. Concept extraction using MetaMap was employed to mine research topics from article titles. Research trends were analyzed from various aspects, including publication amount, journals, research topics and types, and cooperation between authors.ResultsA total of 4473 articles were identified. A rapid growth in publications was witnessed from 2000 to 2015, followed by a plateau. Diabetes, stroke, and dementia were the top 3 most popular research topics whereas statin therapy, metformin, and Chinese herbal medicine were the most investigated interventions. Approximately one-third of the articles were published in open access journals. Studies with two or more medical conditions, but without any intervention, were the most common study type. Studies of this type tended to be contributed by prolific authors and published in OAMJs.ConclusionsThe growth in publication volume during the second decade after the release of the NHI claims database was different from that during the first decade. OAMJs appeared to provide fertile soil for the rapid growth of research based on NHI claims data, in particular for those studies with two or medical conditions in the article title. A halt in the growth of publication volume was observed after the use of NHI claims data for research purposes had been restricted in response to legal controversy. More efforts are needed to improve the impact of knowledge gained from NHI claims data on medical decisions and policy making.

Project description:BackgroundToxicogenomics studies often profile gene expression from assays involving multiple doses and time points. The dose- and time-dependent pattern is of great importance to assess toxicity but computational approaches are lacking to effectively utilize this characteristic in toxicity assessment. Topic modeling is a text mining approach, but may be used analogously in toxicogenomics due to the similar data structures between text and gene dysregulation.ResultsTopic modeling was applied to a very large toxicogenomics dataset containing microarray gene expression data from >15,000 samples associated with 131 drugs tested in three different assay platforms (i.e., in vitro assay, in vivo repeated dose study and in vivo single dose experiment) with a design including multiple doses and time points. A set of "topics" which each consist of a set of genes was determined, by which the varying sensitivity of three assay systems was observed. We found that the drug-dependent effect was more pronounced in the two in vivo systems than the in vitro system, while the time-dependent effect was most strongly reflected in the in vitro system followed by the single dose study and lastly the repeated dose experiment. The dose-dependent effect was similar across three assay systems. Although the results indicated a challenge to extrapolate the in vitro results to the in vivo situation, we did notice that, for some drugs but not for all the drugs, the similarity in gene expression patterns was observed across all three assay systems, indicating a possibility of using in vitro systems with careful designs (such as the choice of dose and time point), to replace the in vivo testing strategy. Nonetheless, a potential to replace the repeated dose study by the single-dose short-term methodology was strongly implied.ConclusionsThe study demonstrated that text mining methodologies such as topic modeling provide an alternative method compared to traditional means for data reduction in toxicogenomics, enhancing researchers' capabilities to interpret biological information.

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Capturing the trend of mHealth research using text mining.

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Capturing the trend of mHealth research using text mining.

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