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Recovery from bradycardia and desaturation events at 32 weeks corrected age and NICU length of stay: an indicator of physiologic resilience?


ABSTRACT: BACKGROUND:Preterm very low birth weight (VLBW) infants experience physiologic maturation and transitions off therapies from 32 to 35 weeks postmenstrual age (PMA), which may impact episodic bradycardia and oxygen desaturation. We sought to characterize bradycardias and desaturations from 32 to 35 weeks PMA and test whether events at 32 weeks PMA are associated with NICU length of stay. METHODS:For 265 VLBW infants from 32 to 35 weeks PMA, we quantified the number and duration of bradycardias (HR <100 for ?4?s) and desaturations (SpO2 <80% for ?10?s) and compared events around discontinuation of CPAP, caffeine, and supplemental oxygen. We modeled associations between clinical variables, bradycardias and desaturations at 32 weeks PMA, and discharge PMA. RESULTS:Desaturations decreased from 60 to 41 per day at 32 and 35 weeks, respectively (p?

SUBMITTER: Nagraj VP 

PROVIDER: S-EPMC6851471 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature

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Recovery from bradycardia and desaturation events at 32 weeks corrected age and NICU length of stay: an indicator of physiologic resilience?

Nagraj V Peter VP   Sinkin Robert A RA   Lake Douglas E DE   Moorman J Randall JR   Fairchild Karen D KD  

Pediatric research 20190704 5


<h4>Background</h4>Preterm very low birth weight (VLBW) infants experience physiologic maturation and transitions off therapies from 32 to 35 weeks postmenstrual age (PMA), which may impact episodic bradycardia and oxygen desaturation. We sought to characterize bradycardias and desaturations from 32 to 35 weeks PMA and test whether events at 32 weeks PMA are associated with NICU length of stay.<h4>Methods</h4>For 265 VLBW infants from 32 to 35 weeks PMA, we quantified the number and duration of  ...[more]

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2005-05-04 | GSE2372 | GEO