Methylenetetrahydrofolate reductase polymorphisms and colorectal cancer prognosis: A meta-analysis.

ABSTRACT:

Background

The present study focused on understanding the prognostic value of the methylenetetrahydrofolate reductase (MTHFR) single nucleotide polymorphisms rs1801133 (C667T) and rs1801131 (A1298C) in patients with colorectal cancer (CRC).

Methods

A systematic literature search was conducted in March 2016. Databases, including Medline, EMBASE, Cochrane and Chinese databases (including CNKI, Wanfang and VIP), were searched to identify the relevant articles describing MTHFR polymorphisms in patients with CRC. Data regarding overall survival (OS), progression-free survival (PFS) and disease-free survival (DFS) were collected and analysed.

Results

Twenty-four studies with 5423 patients with CRC were included. Significant differences in OS, PFS and DFS were not observed a

SUBMITTER: Chen XL 

PROVIDER: S-EPMC6851539 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature