Ontology highlight
ABSTRACT:
SUBMITTER: Huth F
PROVIDER: S-EPMC6851657 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Huth Felix F Gardin Anne A Umehara Kenichi K He Handan H
Clinical pharmacology and therapeutics 20190811 5
We predicted the drug-drug interaction (DDI) potential of siponimod in presence of cytochrome P450 (CYP)2C9/CYP3A4 inhibitors/inducers in subjects with different CYP2C9 genotypes by physiologically-based pharmacokinetic (PK) modeling. The model was established using in vitro and clinical PK data and verified by adequately predicting siponimod PK when coadministered with rifampin. With strong and moderate CYP3A4 inhibitors, an increased DDI risk for siponimod was predicted for CYP2C9*3/*3 genotyp ...[more]