Ontology highlight
ABSTRACT:
SUBMITTER: Plazaola-Sasieta H
PROVIDER: S-EPMC6851788 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Plazaola-Sasieta Haritz H Zhu Qi Q Gaitán-Peñas Héctor H Rios Martín M Estévez Raúl R Morey Marta M
Glia 20190903 12
Glial cells form part of the neural stem cell niche and express a wide variety of ion channels; however, the contribution of these channels to nervous system development is poorly understood. We explored the function of the Drosophila ClC-a chloride channel, since its mammalian ortholog CLCN2 is expressed in glial cells, and defective channel function results in leukodystrophies, which in humans are accompanied by cognitive impairment. We found that ClC-a was expressed in the niche in cortex gli ...[more]