Ontology highlight
ABSTRACT:
SUBMITTER: Dubessy AL
PROVIDER: S-EPMC6851800 | biostudies-literature | 2019 Dec
REPOSITORIES: biostudies-literature
Dubessy Anne-Laure AL Mazuir Elisa E Rappeneau Quentin Q Ou Sokounthie S Abi Ghanem Charly C Piquand Kevin K Aigrot Marie-Stéphane MS Thétiot Melina M Desmazières Anne A Chan Eric E Fitzgibbon Matt M Fleming Mark M Krauss Raul R Zalc Bernard B Ranscht Barbara B Lubetzki Catherine C Sol-Foulon Nathalie N
Glia 20190722 12
The fast and reliable propagation of action potentials along myelinated fibers relies on the clustering of voltage-gated sodium channels at nodes of Ranvier. Axo-glial communication is required for assembly of nodal proteins in the central nervous system, yet the underlying mechanisms remain poorly understood. Oligodendrocytes are known to support node of Ranvier assembly through paranodal junction formation. In addition, the formation of early nodal protein clusters (or prenodes) along axons pr ...[more]