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ABSTRACT:
SUBMITTER: Muhlhaus F
PROVIDER: S-EPMC6852184 | biostudies-literature | 2019 Oct
REPOSITORIES: biostudies-literature
Mühlhaus Felix F Weißbarth Hendrik H Dahmen Tobias T Schnakenburg Gregor G Gansäuer Andreas A
Angewandte Chemie (International ed. in English) 20190828 40
A titanocene-catalyzed regiodivergent radical arylation is described that allows access to either enantiomerically pure tetrahydroquinolines or indolines from a common starting material. The regioselectivity of epoxide opening that results in the high selectivity of heterocycle formation is controlled by two factors, the absolute configuration of the enantiopure ligands of the (C<sub>5</sub> H<sub>4</sub> R)<sub>2</sub> TiX<sub>2</sub> catalyst and the inorganic ligand X (X=Cl, OTs). The overall ...[more]