Ontology highlight
ABSTRACT:
SUBMITTER: Grinnan D
PROVIDER: S-EPMC6852366 | biostudies-literature | 2019 Jan-Mar
REPOSITORIES: biostudies-literature
Grinnan Daniel D Trankle Cory C Andruska Adam A Bloom Bruce B Spiekerkoetter Edda E
Pulmonary circulation 20190101 1
Despite many advances in medical therapy for pulmonary arterial hypertension (PAH) over the past 20 years, long-term survival is still poor. Novel therapies which target the underlying pathology of PAH and which could be added to current vasodilatory therapies to halt disease progression and potentially reverse pulmonary vascular remodeling are highly sought after. Given the high attrition rates, substantial costs, and slow pace of new drug development, repositioning of "old" drugs is increasing ...[more]