Dataset Information

Accurate Whole-Brain Segmentation for Alzheimer's Disease Combining an Adaptive Statistical Atlas and Multi-atlas.

ABSTRACT: Accurate segmentation of whole brain MR images including the cortex, white matter and subcortical structures is challenging due to inter-subject variability and the complex geometry of brain anatomy. However a precise solution would enable accurate, objective measurement of structure volumes for disease quantification. Our contribution is three-fold. First we construct an adaptive statistical atlas that combines structure specific relaxation and spatially varying adaptivity. Second we integrate an isotropic pairwise class-specific MRF model of label connectivity. Together these permit precise control over adaptivity, allowing many structures to be segmented simultaneously with superior accuracy. Third, we develop a framework combining the improved adaptive statistical atlas with a multi-atlas method which achieves simultaneous accurate segmentation of the cortex, ventricles, and sub-cortical structures in severely diseased brains, a feat not attained in [18]. We test the proposed method on 46 brains including 28 diseased brain with Alzheimer's and 18 healthy brains. Our proposed method yields higher accuracy than state-of-the-art approaches on both healthy and diseased brains.

SUBMITTER: Yan Z

PROVIDER: S-EPMC6853627 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature

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Publications

Accurate Whole-Brain Segmentation for Alzheimer's Disease Combining an Adaptive Statistical Atlas and Multi-atlas.

Yan Zhennan Z Zhang Shaoting S Liu Xiaofeng X Metaxas Dimitris N DN Montillo Albert A

Medical computer vision : large data in medical imaging : third international MICCAI workshop, MCV 2013, Nagoya, Japan, September 26, 2013 : revised selected papers. MCV (Workshop) (3rd : 2013 : Nagoya-shi, Japan) 20140401

Accurate segmentation of whole brain MR images including the cortex, white matter and subcortical structures is challenging due to inter-subject variability and the complex geometry of brain anatomy. However a precise solution would enable accurate, objective measurement of structure volumes for disease quantification. Our contribution is three-fold. First we construct an adaptive statistical atlas that combines structure specific relaxation and spatially varying adaptivity. Second we integrate ...[more]

PMID: 31723945

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Project description:Multi-atlas segmentation has been shown to be highly robust and accurate across an extraordinary range of potential applications. However, it is limited to the segmentation of structures that are anatomically consistent across a large population of potential target subjects (i.e., multi-atlas segmentation is limited to "in-atlas" applications). Herein, the authors propose a technique to determine the likelihood that a multi-atlas segmentation estimate is representative of the problem at hand, and, therefore, identify anomalous regions that are not well represented within the atlases.The authors derive a technique to estimate the out-of-atlas (OOA) likelihood for every voxel in the target image. These estimated likelihoods can be used to determine and localize the probability of an abnormality being present on the target image.Using a collection of manually labeled whole-brain datasets, the authors demonstrate the efficacy of the proposed framework on two distinct applications. First, the authors demonstrate the ability to accurately and robustly detect malignant gliomas in the human brain-an aggressive class of central nervous system neoplasms. Second, the authors demonstrate how this OOA likelihood estimation process can be used within a quality control context for diffusion tensor imaging datasets to detect large-scale imaging artifacts (e.g., aliasing and image shading).The proposed OOA likelihood estimation framework shows great promise for robust and rapid identification of brain abnormalities and imaging artifacts using only weak dependencies on anomaly morphometry and appearance. The authors envision that this approach would allow for application-specific algorithms to focus directly on regions of high OOA likelihood, which would (1) reduce the need for human intervention, and (2) reduce the propensity for false positives. Using the dual perspective, this technique would allow for algorithms to focus on regions of normal anatomy to ascertain image quality and adapt to image appearance characteristics.

Dataset Information

Accurate Whole-Brain Segmentation for Alzheimer's Disease Combining an Adaptive Statistical Atlas and Multi-atlas.

Publications

Accurate Whole-Brain Segmentation for Alzheimer's Disease Combining an Adaptive Statistical Atlas and Multi-atlas.

Similar Datasets

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