Ontology highlight
ABSTRACT:
SUBMITTER: Arroyo G
PROVIDER: S-EPMC6853673 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Arroyo Gianfranco G Bustos Javier A JA Lescano Andres G AG Gonzales Isidro I Saavedra Herbert H Rodriguez Silvia S Pretell E Javier EJ Bonato Pierina S PS Lanchote Vera L VL Takayanagui Osvaldo M OM Horton John J Gonzalez Armando E AE Gilman Robert H RH Garcia Hector H HH
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20191101 11
<h4>Background</h4>The efficacy of albendazole therapy in patients with parenchymal neurocysticercosis (NCC) is suboptimal. Plasma levels of albendazole sulfoxide (ASOX), the active metabolite of albendazole, are highly variable among patients. We hypothesized that high ASOX plasma levels during albendazole therapy may be associated with an increased antiparasitic efficacy.<h4>Methods</h4>ASOX plasma levels were measured at treatment day 7 in 118 patients with parenchymal NCC enrolled in a treat ...[more]