Ontology highlight
ABSTRACT:
SUBMITTER: Boscolo Sesillo F
PROVIDER: S-EPMC6853774 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Boscolo Sesillo Francesca F Fox David D Sacco Alessandra A
Cell reports 20190101 3
Most human cancers originate from high-turnover tissues, while low-proliferating tissues, like skeletal muscle, exhibit a lower incidence of tumor development. In Duchenne muscular dystrophy (DMD), which induces increased skeletal muscle regeneration, tumor incidence is increased. Rhabdomyosarcomas (RMSs), a rare and aggressive type of soft tissue sarcoma, can develop in this context, but the impact of DMD severity on RMS development and its cell of origin are poorly understood. Here, we show th ...[more]