Crystal structures of a GABAA-receptor chimera reveal new endogenous neurosteroid-binding sites.
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ABSTRACT:
SUBMITTER: Laverty D
PROVIDER: S-EPMC6853794 | biostudies-literature | 2017 Nov
REPOSITORIES: biostudies-literature
Publications
Crystal structures of a GABA<sub>A</sub>-receptor chimera reveal new endogenous neurosteroid-binding sites.
Laverty Duncan D Thomas Philip P Field Martin M Andersen Ole J OJ Gold Matthew G MG Biggin Philip C PC Gielen Marc M Smart Trevor G TG
Nature structural & molecular biology 20171002 11
γ-Aminobutyric acid receptors (GABA<sub>A</sub>Rs) are vital for controlling excitability in the brain. This is emphasized by the numerous neuropsychiatric disorders that result from receptor dysfunction. A critical component of most native GABA<sub>A</sub>Rs is the α subunit. Its transmembrane domain is the target for many modulators, including endogenous brain neurosteroids that impact anxiety, stress and depression, and for therapeutic drugs, such as general anesthetics. Understanding the bas ...[more]
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