Differential Expression of Inflammation-Related Genes in Down Syndrome Patients with or without Periodontal Disease.

ABSTRACT:

Aim

Aware that Down Syndrome patients present among their clinical characteristics impaired immunity, the aim of this study is to identify the statistically significant differences in inflammation-related gene expression by comparing Down Syndrome patients with Periodontal Disease (DS+PD+) with Down Syndrome patients without Periodontal Disease (DS+PD-), and their relationship with periodontitis as a chronic oral inflammatory clinical feature.

Materials and methods

Case study and controls on eleven Down Syndrome patients (DS+PD+ vs. DS+PD-). RNA was extracted from peripheral blood using a Qiagen PAXgene Blood miRNA Kit when performing an oral examination. A search for candidate genes (92 selected) was undertaken on the total genes obtained using a Scientific GeneChip® Scanne

SUBMITTER: Baus-Dominguez M 

PROVIDER: S-EPMC6854216 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature