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Plasma Betatrophin Levels and Carotid Atherosclerosis.

ABSTRACT: Aims:Betatrophin is a recently identified circulating adipokine that may affect lipid and glucose metabolism. However, the association between plasma betatrophin levels and carotid atherosclerosis has not been elucidated. Methods:We investigated plasma betatrophin levels in 153 subjects undergoing carotid ultrasonography. The severity of plaque was evaluated as plaque score. Results:Of the 153 subjects, plaque was found in 63 (41%). Plasma betatrophin levels were higher in 63 subjects with plaque than in 90 without plaque (median 906 vs. 729?pg/mL, P < 0.025). A stepwise increase in betatrophin levels was found depending on the plaque score: 729?pg/mL in score = 0 (n = 90), 802?pg/mL in score = 1 (n = 31), and 978?pg/mL in score ? 2 (n = 32) (P < 0.01). In particular, betatrophin levels in subjects with score ? 2 were higher than in those with score = 0 (P < 0.05). Moreover, betatrophin levels correlated with plaque score (r = 0.23, P < 0.01), but no significant correlation was found between betatrophin levels and triglyceride or HbA1c levels. The percentage of subjects with betatrophin > 800?pg/mL was higher in subjects with plaque than in those without plaque (65% vs. 44%) and was highest in score ? 2 (78%) (P < 0.005). In the multivariate analysis, betatrophin level was not a significant factor for the presence of plaque but was a significant factor for plaque score ? 2, independent of atherosclerotic risk factors. The odds ratio for score ? 2 was 4.9 (95% CI = 1.9-12.8) for betatrophin > 800?pg/mL. Conclusions:Plasma betatrophin levels were found to be high in subjects with carotid plaque and to be associated with the severity of plaque. Betatrophin may play a role in the progression of carotid atherosclerosis.

SUBMITTER: Niki H

PROVIDER: S-EPMC6854246 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Plasma Betatrophin Levels and Carotid Atherosclerosis.

Niki Hanako H Kishimoto Yoshimi Y Saita Emi E Ohmori Reiko R Kondo Kazuo K Momiyama Yukihiko Y

Disease markers 20191017

<h4>Aims</h4>Betatrophin is a recently identified circulating adipokine that may affect lipid and glucose metabolism. However, the association between plasma betatrophin levels and carotid atherosclerosis has not been elucidated.<h4>Methods</h4>We investigated plasma betatrophin levels in 153 subjects undergoing carotid ultrasonography. The severity of plaque was evaluated as plaque score.<h4>Results</h4>Of the 153 subjects, plaque was found in 63 (41%). Plasma betatrophin levels were higher in ...[more]

PMID: 31772685

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Project description:ObjectiveTo evaluate plasma acylcarnitine profiles and their relationships with progression of carotid artery atherosclerosis among individuals with and without HIV infection.DesignProspective cohort studies of 499 HIV-positive and 206 HIV-negative individuals from the Women's Interagency HIV Study and the Multicenter AIDS Cohort Study.MethodsTwenty-four acylcarnitine species were measured in plasma samples of participants at baseline. Carotid artery plaque was assessed using repeated B-mode carotid artery ultrasound imaging in 2004-2013. We examined the associations of individual and aggregate short-chain (C2-C7), medium-chain (C8-C14) and long-chain acylcarnitines (C16-C26) with incident carotid artery plaque over 7 years.ResultsAmong 24 acylcarnitine species, C8-carnitines and C20 : 4-carnitines showed significantly lower levels comparing HIV-positive to HIV-negative individuals (false discovery rate adjusted P < 0.05); and C20-carnitines and C26-carnitines showed significantly higher levels in HIV positive using antiretroviral therapy than those without antiretroviral therapy (false discovery rate adjusted P < 0.05). In the univariate analyses, higher aggregated short-chain and long-chain acylcarnitine scores were associated with increased risk of carotid artery plaque [risk ratios (RRs) = 1.22 (95% confidence interval 1.02-1.45) and 1.20 (1.02-1.41) per SD increment, respectively]. The association for the short-chain acylcarnitine score remained significant [RR = 1.23 (1.05-1.44)] after multivariate adjustment (including traditional cardiovascular disease risk factors). This association was more evident in HIV-positive individuals without persistent viral suppression [RR = 1.37 (1.11-1.69)] compared with those with persistent viral suppression during follow-up [RR = 1.03 (0.76-1.40)] or HIV-negative individuals [RR = 1.02 (0.69-1.52)].ConclusionIn two HIV cohorts, plasma levels of most acylcarnitines were not significantly different between HIV-positive and HIV-negative individuals. However, higher levels of aggregated short-chain acylcarnitines were associated with progression of carotid artery atherosclerosis.

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Plasma Betatrophin Levels and Carotid Atherosclerosis.

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Plasma Betatrophin Levels and Carotid Atherosclerosis.

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