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Biocompatible Dendrimer-Encapsulated Palladium Nanoparticles for Oxidation of Morin.

ABSTRACT: Development of highly efficient catalysts to expedite the degradation of organic dyes has been drawing great attention. The aggregation of catalysts reduces the accessibility of catalytic centers for organic dyes and therefore decreases their catalytic ability. Herein, we report a facile method to prepare highly biocompatible and stable dendrimer-encapsulated palladium nanoparticles (Pd _n -G5MCI NPs), which exhibit high catalytic efficiency for oxidation of morin. The biocompatible dendrimers were prepared via surface modification of G5 polyamidoamine (G5 PAMAM) dendrimers using maleic anhydride and l-cysteine. Then, they were incubated with disodium tetrachloropalladate, followed by reduction using sodium borohydride to generate Pd _n -G5MCI NPs. Transmission electron microscopy results demonstrated that palladium nanoparticles (Pd NPs) inside Pd _n -G5MCI had small diameters (1.77-2.35 nm) and monodisperse states. Dynamic light scattering results confirmed that Pd _n -G5MCI NPs had good dispersion and high stability in water. Furthermore, MTT results demonstrated that Pd _n -G5MCI NPs had high biocompatibility. More importantly, Pd _n -G5MCI NPs successfully catalyzed the decomposition of H₂O₂ to the hydroxyl radical (^•OH), and the generated ^•OH quickly oxidized morin. This reaction kinetics followed pseudo-first-order kinetics. Apparent rate constant (k _app) is an important criterion for evaluating the catalytic rate. The concentrations of Pd _n -G5MCI NPs and H₂O₂ were positively correlated with k _app, whereas the correlation between the concentration of morin and k _app was negative. The prepared Pd _n -G5MCI NPs have great potential to catalyze the degradation of organic dyes in bio-related systems in the future.

SUBMITTER: Xiao H

PROVIDER: S-EPMC6854556 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature

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Biocompatible Dendrimer-Encapsulated Palladium Nanoparticles for Oxidation of Morin.

Xiao Haiyan H Wang Ran R Dong Le L Cui Yanshuai Y Chen Shengfu S Sun Haotian H Ma Guanglong G Gao Dawei D Wang Longgang L

ACS omega 20191030 20

Development of highly efficient catalysts to expedite the degradation of organic dyes has been drawing great attention. The aggregation of catalysts reduces the accessibility of catalytic centers for organic dyes and therefore decreases their catalytic ability. Herein, we report a facile method to prepare highly biocompatible and stable dendrimer-encapsulated palladium nanoparticles (Pd <sub><i>n</i></sub> -G5MCI NPs), which exhibit high catalytic efficiency for oxidation of morin. The biocompat ...[more]

PMID: 31737829

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Project description:Chronic exposure to arsenic over a period of time induces toxicity, primarily in the liver but gradually in all systems of the body. Morin hydrate (MH; 2',3,4',5,7-pentahydroxyflavone), a potent flavonoid abundantly present in plants of the Moraceae family, is thought to be a major bioactive compound that may be used to prevent a wide range of disease pathologies including hepatotoxicity. Therapeutic applications of morin (MOR) are however seriously constrained because of its insolubility, poor bioavailability, high metabolism and rapid elimination from the human body. Nanoformulation of MOR is a possible solution to these problems. In the present study we investigated the effectiveness of morin encapsulated chitosan nanoparticles (MCNPs) against arsenic induced liver damage in mice. MNCPs with an average diameter of 124.5 nm, a zeta potential of +16.2 mV and an encapsulation efficiency of 78% were prepared. Co-treatment of MOR and MCNPs by oral gavage on alternate days reduced the serum levels of AST, ALT, and ALP that were elevated in arsenic treated mice. The efficiency of MCNPs was found to be nearly 4 times higher than that of free MOR. Haematological and serum biochemical parameters including lipid profiles altered by arsenic were normalized following MCNP treatment. Arsenic deposition was lowered in the presence of MCNPs. Administration of MCNPs markedly inhibited ROS generation and elevated MDA levels in arsenic exposed mice. The level of hepatic antioxidant factors such as nuclear Nrf2 (Nrf2), superoxide dismutase (SOD), catalase (CAT), glutathione (GSH), GSH peroxidase (GPx), glutathione-S-transferase (GST), heme oxygenase-1 (HO-1), and NADPH quinone oxidoreductase 1(NQO1) were markedly enhanced in the arsenic + MCNP group. Treatment by MCNPs prevented the arsenic induced damage of tissue histology. Also, MCNPs suppressed the arsenic induced pro- and anti-apoptotic parameters and attenuated the level of inflammatory mediators. Our data suggest that MCNPs are good hepatoprotective agents compared to free morin against arsenic induced toxicity and the protective effect results from its strong antioxidant, antiapoptotic and anti-inflammatory properties.

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Biocompatible Dendrimer-Encapsulated Palladium Nanoparticles for Oxidation of Morin.

Publications

Biocompatible Dendrimer-Encapsulated Palladium Nanoparticles for Oxidation of Morin.

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