Ontology highlight
ABSTRACT:
SUBMITTER: Heppt MV
PROVIDER: S-EPMC6854774 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Heppt Markus V MV Amaral Teresa T Kähler Katharina C KC Heinzerling Lucie L Hassel Jessica C JC Meissner Markus M Kreuzberg Nicole N Loquai Carmen C Reinhardt Lydia L Utikal Jochen J Dabrowski Evelyn E Gesierich Anja A Pföhler Claudia C Terheyden Patrick P Thoms Kai-Martin KM Zimmer Lisa L Eigentler Thomas K TK Kirchberger Michael C MC Stege Henner M HM Meier Friedegund F Schlaak Max M Berking Carola C
Journal for immunotherapy of cancer 20191113 1
<h4>Background</h4>Uveal melanoma (UM) is highly refractory to treatment with dismal prognosis in advanced stages. The value of the combined checkpoint blockade with CTLA-4 and PD-1 inhibition in metastatic UM is currently unclear.<h4>Methods</h4>Patients with metastatic or unresectable UM treated with ipilimumab in combination with a PD-1 inhibitor were collected from 16 German skin cancer centers. Patient records of 64 cases were analyzed for response, progression-free survival (PFS), overall ...[more]