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Concise and Efficient Synthesis of Indole-Indolone Scaffolds through MeOTf-Induced Annulation of N-(2-Cyanoaryl)indoles.

ABSTRACT: MeOTf-triggered annulation of N-(2-cyanoaryl)indoles to provide indolo[1,2-a]indol-10-imines and the corresponding indolo[1,2-a]indol-10-ones have been described under metal-free conditions. A variety of functional groups are tolerated in their scaffolds with good to excellent yields. The reaction could be carried to gram scale.

SUBMITTER: Zou S

PROVIDER: S-EPMC6854827 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature

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Concise and Efficient Synthesis of Indole-Indolone Scaffolds through MeOTf-Induced Annulation of N-(2-Cyanoaryl)indoles.

Zou Song S Liu Yu Y Xi Chanjuan C

ACS omega 20191029 20

MeOTf-triggered annulation of N-(2-cyanoaryl)indoles to provide indolo[1,2-a]indol-10-imines and the corresponding indolo[1,2-a]indol-10-ones have been described under metal-free conditions. A variety of functional groups are tolerated in their scaffolds with good to excellent yields. The reaction could be carried to gram scale. ...[more]

PMID: 31737835

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