Evolutionary determinants of genome-wide nucleotide composition.
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ABSTRACT:
SUBMITTER: Long H
PROVIDER: S-EPMC6855595 | biostudies-literature | 2018 Feb
REPOSITORIES: biostudies-literature
Publications
Evolutionary determinants of genome-wide nucleotide composition.
Long Hongan H Sung Way W Kucukyildirim Sibel S Williams Emily E Miller Samuel F SF Guo Wanfeng W Patterson Caitlyn C Gregory Colin C Strauss Chloe C Stone Casey C Berne Cécile C Kysela David D Shoemaker William R WR Muscarella Mario E ME Luo Haiwei H Lennon Jay T JT Brun Yves V YV Lynch Michael M
Nature ecology & evolution 20180101 2
One of the long-standing mysteries of evolutionary genomics is the source of the wide phylogenetic diversity in genome nucleotide composition (G + C versus A + T), which must be a consequence of interspecific differences in mutation bias, the efficiency of selection for different nucleotides or a combination of the two. We demonstrate that although genomic G + C composition is strongly driven by mutation bias, it is also substantially modified by direct selection and/or as a by-product of biased ...[more]
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