Ontology highlight
ABSTRACT:
SUBMITTER: El Ayachi I
PROVIDER: S-EPMC6855600 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
El Ayachi Ikbale I Fatima Iram I Wend Peter P Alva-Ornelas Jackelyn A JA Runke Stephanie S Kuenzinger William L WL Silva Julio J Silva Wendy W Gray Joseph K JK Lehr Stephan S Barch Hilaire C HC Krutilina Raisa I RI White Andrew C AC Cardiff Robert R Yee Lisa D LD Yang Lily L O'Regan Ruth M RM Lowry William E WE Seagroves Tiffany N TN Seewaldt Victoria V Krum Susan A SA Miranda-Carboni Gustavo A GA
Cancer research 20181218 5
Triple-negative breast cancer (TNBC) commonly develops resistance to chemotherapy, yet markers predictive of chemoresistance in this disease are lacking. Here, we define WNT10B-dependent biomarkers for β-CATENIN/HMGA2/EZH2 signaling predictive of reduced relapse-free survival. Concordant expression of HMGA2 and EZH2 proteins is observed in <i>MMTV</i>-<i>Wnt10b<sup>LacZ</sup></i> transgenic mice during metastasis, and <i>Hmga2</i> haploinsufficiency decreased EZH2 protein expression, repressing ...[more]