Ontology highlight
ABSTRACT:
SUBMITTER: Chew TA
PROVIDER: S-EPMC6856059 | biostudies-literature | 2019 Aug
REPOSITORIES: biostudies-literature
Chew Thomas A TA Orlando Benjamin J BJ Zhang Jinru J Latorraca Naomi R NR Wang Amy A Hollingsworth Scott A SA Chen Dong-Hua DH Dror Ron O RO Liao Maofu M Feng Liang L
Nature 20190731 7770
Cation-chloride cotransporters (CCCs) mediate the electroneutral transport of chloride, potassium and/or sodium across the membrane. They have critical roles in regulating cell volume, controlling ion absorption and secretion across epithelia, and maintaining intracellular chloride homeostasis. These transporters are primary targets for some of the most commonly prescribed drugs. Here we determined the cryo-electron microscopy structure of the Na-K-Cl cotransporter NKCC1, an extensively studied ...[more]