Ontology highlight
ABSTRACT:
SUBMITTER: Piccinin E
PROVIDER: S-EPMC6856160 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Piccinin Elena E Ducheix Simon S Peres Claudia C Arconzo Maria M Vegliante Maria Carmela MC Ferretta Anna A Bellafante Elena E Villani Gaetano G Moschetta Antonio A
Scientific reports 20191114 1
Acetaminophen (APAP) is a worldwide commonly used painkiller drug. However, high doses of APAP can lead to acute hepatic failure and, in some cases, death. Previous studies indicated that different factors, including life-style and metabolic diseases, could predispose to the risk of APAP-induced liver failure. However, the molecular process that could favor APAP hepatotoxicity remains understood. Here, we reported that a short-term high fat-enriched diet worsens APAP-induced liver damage, by pro ...[more]