Transplanted interneurons improve memory precision after traumatic brain injury.
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ABSTRACT:
SUBMITTER: Zhu B
PROVIDER: S-EPMC6856380 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Publications
Transplanted interneurons improve memory precision after traumatic brain injury.
Zhu Bingyao B Eom Jisu J Hunt Robert F RF
Nature communications 20191114 1
Repair of the traumatically injured brain has been envisioned for decades, but regenerating new neurons at the site of brain injury has been challenging. We show GABAergic progenitors, derived from the embryonic medial ganglionic eminence, migrate long distances following transplantation into the hippocampus of adult mice with traumatic brain injury, functionally integrate as mature inhibitory interneurons and restore post-traumatic decreases in synaptic inhibition. Grafted animals had improveme ...[more]
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