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A 57-Year-Old Woman With Progressive Left Hand Clumsiness and Falls.

ABSTRACT: Clinical History:A 57-year old woman presented with left hand pain, periodic leg movement during sleep, gradual onset of stiffness, clumsiness, and falls. Neurological examination showed: generalized rigidity and bradykinesia. There was left hand dystonic posturing and ideomotor apraxia, as well as mirror movements of upper limbs and stimulus-sensitive myoclonus. The patient had a high-pitched voice and hypophonia (Video S1). Discussion:Experts discuss localization and the syndromic diagnosis and predict the underlying pathology. The pathological diagnosis is then provided and clinical learning points are considered.

SUBMITTER: Paramanandam V 

PROVIDER: S-EPMC6856468 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature

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A 57-Year-Old Woman With Progressive Left Hand Clumsiness and Falls.

Paramanandam Vijayashankar V   Olszewska Diana Angelika DA   Shakya Bhattacharjee B   Chalissery Albi Jose AJ   O'Connell Martin M   Farrell Michael M   Lynch Tim T  

Movement disorders clinical practice 20190916 8

<h4>Clinical history</h4>A 57-year old woman presented with left hand pain, periodic leg movement during sleep, gradual onset of stiffness, clumsiness, and falls. Neurological examination showed: generalized rigidity and bradykinesia. There was left hand dystonic posturing and ideomotor apraxia, as well as mirror movements of upper limbs and stimulus-sensitive myoclonus. The patient had a high-pitched voice and hypophonia (Video S1).<h4>Discussion</h4>Experts discuss localization and the syndrom  ...[more]

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