Ontology highlight
ABSTRACT:
SUBMITTER: Hoglund J
PROVIDER: S-EPMC6856527 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Höglund Julia J Rafati Nima N Rask-Andersen Mathias M Enroth Stefan S Karlsson Torgny T Ek Weronica E WE Johansson Åsa Å
Scientific reports 20191114 1
Genome-wide association studies (GWAS) have identified associations between thousands of common genetic variants and human traits. However, common variants usually explain a limited fraction of the heritability of a trait. A powerful resource for identifying trait-associated variants is whole genome sequencing (WGS) data in cohorts comprised of families or individuals from a limited geographical area. To evaluate the power of WGS compared to imputations, we performed GWAS on WGS data for 72 infl ...[more]